Compatibility tables

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Below are product summary and stability tables for the Fresenius Kabi range of MCBs.

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MCBs provide macronutrients and help to meet nutritional requirements based on individual needs and clinical condition. PN should be monitored, and doses adjusted according to individual patient response. Please refer to the Summary of Product Characteristics before prescribing. Fresenius Kabi’s MCBs are licensed for use in adults and children ≥2 years of age.

MCB = Multi-chamber bag; PN = Parenteral Nutrition

SmofKabiven® extra Nitrogen1,2

(amino acids, +/- electrolytes, glucose, lipid emulsion)

  SmofKabiven extra Nitrogen 11gN SmofKabiven extra Nitrogen 16gN SmofKabiven extra Nitrogen 21gN SmofKabiven extra Nitrogen 21gN EF
Volume (ml) 1012 1518 2025 2025
Amino acids (g) 66.3 99.4 133 133
Nitrogen (g) 10.6 15.9 21.2 21.2
Fat (g) 29.2 43.8 58.4 58.4
Glucose (g) 85.7 129 171 171
Energy
Total (kcal) 900 1350 1800 1800
Non-protein (kcal) 635 952 1270 1270
Lipid (kcal) 292 438 584 584
Carbohydrate (kcal) 343 514 686 686
N:Non-protein energy (g:kcal) 1:60 1:60 1:60 1:60
Energy ratio Carbohydrate:Lipid (%:%) 54:46 54:46 54:46 54:46
Electrolyte contents in the bags
Sodium (mmol) 41.3 61.9 82.6 Nil
Potassium (mmol) 30.9 46.4 61.9 Nil
Magnesium (mmol) 5.2 7.7 10.3 Nil
Calcium (mmol) 2.6 3.9 5.2 Nil
Phosphate (mmol)* 12.9 19.3 25.8 4.4
Zinc (µmol) 40 60 80 Nil
Chloride (mmol) 36.1 54.1 72.2 Nil
Acetate (mmol) 126 189 253 194
Osmolarity (mosmol/l) 1300 1200
Osmolality (mosmol/kg.water) 1600 1400
Further additions can be added to the bags for an expiry of 6 days at 2-8°C followed by 24 hours at 20 - 25°C*** These values are maximum totals and include contribution from the bag.
Sodium (mmol) 150 225 300 300
Potassium (mmol) 150 225 300 300
Magnesium (mmol)** 5 7.5 10 10
Calcium (mmol) 5 7.5 10 10
Inorganic phosphate (mmol) OR Sodium glycerophosphate (mmol) 15
OR
30		 22.5
OR
45		 30
OR
60		 30
OR
60
Zinc (µmol)∆ 200 300 400 400
Selenium (nmol)∆ 2000 3000 4000 4000
Dipeptiven® (ml)† 300 300 300 300
Addaven® (ml)† 20 20 20 20
Solivito® (Vial)† 2 2 2 2
Vitlipid® N Adult (ml)† 20 20 20 20
Extra maximum volumes that can be added to the bag for a 6 day expiry***
Glucose 5% (ml) (6 days) or 0-500 0-500 0-500 0-500
NaCl 0.9% (ml) (6 days) 0-500 0-500 0-500 0-500

All figures are approximate
* Contribution from both the lipid and amino acid solution.
** The magnesium total may be increased as long as the combined concentration of magnesium and calcium does not
exceed 10mmol/litre.
*** Must be stored between 2–8°C. Extended stability data may be available, please contact Fresenius Kabi Medical
Information if required. Additions made to SmofKabiven extra Nitrogen are outside the scope of the product licence.
The mixing of licensed products results in the formation of an unlicensed product.
Δ Including the amount from Addaven.
† For further information on these additions, please contact Fresenius Kabi Limited Medical Information on 01928 533575
or via email at medical.information-UK@fresenius-kabi.com.

SmofKabiven® Central3,4

(amino acids, +/- electrolytes, glucose, lipid emulsion)

SmofKabiven® Peripheral5

(amino acids, electrolytes, glucose, lipid emulsion)

  SmofKabiven (central) 4gN SmofKabiven (central) 8gN SmofKabiven (central) 12gN SmofKabiven (central) 16gN SmofKabiven (central) 8gN EF SmofKabiven (central) 12gN EF SmofKabiven (central) 16gN EF SmofKabiven (Peripheral) 9.8gN
Volume (ml) 493 986 1477 1970 986 1477 1970 1904
Amino acids (g) 25 50 75 100 50 75 100 60
Nitrogen (g) 4 8 12 16 8 12 16 9.8
Fat (g) 19 38 56 75 38 56 75 54
Glucose (g) 63 125 187 250 125 187 250 135
Energy
Total (kcal) 550 1100 1600 2200 1100 1600 2200 1300
Non-protein (kcal) 450 900 1300 1800 900 1300 1800 1100
Lipid (kcal) 200 400 552 800 400 552 800 550
Carbohydrate (kcal) 250 500 748 1000 500 748 1000 550
N:Non-protein energy (g:kcal) 1:108 1:108 1:108 1:108 1:108 1:108 1:108 1:110
Energy ratio Carbohydrate:Lipid (%:%) 58:42 58:42 58:42 58:42 58:42 58:42 58:42 50:50
Electrolyte contents in the bags
Sodium (mmol) 20 40 60 80 Nil Nil Nil 48
Potassium (mmol) 15 30 45 60 Nil Nil Nil 36
Magnesium (mmol) 2.5 5 7.5 10 Nil Nil Nil 6
Calcium (mmol) 1.3 2.5 3.8 5 Nil Nil Nil 3
Phosphate (mmol)* 6 12 19 25 2.8 4.2 5.6 15.6
Zinc (µmol) 20 40 60 80 Nil Nil Nil 50
Chloride (mmol) 18 35 52 70 Nil Nil Nil 42
Acetate (mmol) 52 104 157 209 73 110 147 125
Osmolarity (mosmol/l) 1500 1300 850
Osmolality (mosmol/kg.water) 1800 1600 950
Further additions can be added to the bags for an expiry of 6 days at 2-8°C followed by 24 hours at 20-25°C** These values are maximum totals and include contribution from the bag
Sodium (mmol) 75 150 225 300 150 225 300 300
Potassium (mmol) 75 150 225 300 150 225 300 300
Magnesium (mmol) 2.5 5 7.5 10 5 7.5 10 10
Calcium (mmol) 2.5 5 7.5 10 5 7.5 10 10
Inorganic phosphate (mmol) OR Sodium glycerophosphate (mmol) 7.5
OR
15		 15
OR
30		 22.5
OR
45		 30
OR
60		 15
OR
30		 22.5
OR
45		 30
OR
60		 30
OR
60
Zinc (µmol)∆ 120 200 250 300 200 250 300 300
Selenium (nmol)∆ 1000 1000 1000 1000 1000 1000 1000 1000
Dipeptiven® (ml)† 100 150 250 300 150 250 300 300
Addaven® (ml)† 10 10 10 10 10 10 10 10
Solivito® (Vial)† 1 1 1 1 1 1 1 1
Vitlipid® N Adult (ml)† 10 10 10 10 10 10 10 10
Extra maximum volumes that can be added to the bag for a 6, 4, or 3 day expiry**
Glucose 5% (ml) (6 days) or Not applicable 0-500 0-500 0-500 0-500 0-500 0-500 0-500
Glucose 20% (ml) (3 days) or Not applicable 0-500 0-500 0-500 0-500 0-500 0-500 0-500
NaCl 0.9% (ml) (4 days) or Not applicable 0-500 0-500 0-500 0-500 0-500 0-500 0-500
Water for injection (ml) (4 days) Not applicable 0-500 0-500 0-500 0-500 0-500 0-500 0-500

All figures are approximate.
* Contribution from both the lipid and amino acid solution
** Must be stored between 2-8˚C. Extended stability data may be available, please contact Fresenius Kabi Medical Information if required. Additions made to SmofKabiven are outside the scope of the product licence. The mixing of licensed products results in the formation of an unlicensed product.
∆ Including the amount from Addaven.
† For further information on these additions, please contact Fresenius Kabi Limited Medical Information on 01928 533575 or via email at medical.information-UK@fresenius-kabi.com.    

SmofKabiven® Low Osmo Peripheral6

(amino acids, electrolytes, glucose, lipid emulsion)

  SmofKabiven
Low Osmo Peripheral 6gN		 SmofKabiven
Low Osmo Peripheral 8gN		 SmofKabiven
Low Osmo Peripheral 10gN
Volume (ml) 1400 1950 2500
Amino acids (g) 35 48.8 62.6
Nitrogen (g) 5.6 7.81 10
Fat (g) 49 68.2 87.6
Glucose (g) 95.1 132 170
Energy
Total (kcal) 1000 1400 1800
Non-protein (kcal) 872 1215 1559
Lipid (kcal) 490 682 876
Carbohydrate (kcal) 382 533 683
N:Non-protein energy (g:kcal) 1:156 1:156 1:156
Energy ratio Carbohydrate:Lipid (%:%) 44:56 44:56 44:56
Electrolyte contents in the bags
Sodium (mmol) 28 39 50
Potassium (mmol) 21 29 38
Magnesium (mmol) 3.5 4.9 6.3
Calcium (mmol) 1.8 2.5 3.1
Phosphate (mmol)* 10 15 19
Zinc (µmol) 28 39 50
Chloride (mmol) 25 34 44
Acetate (mmol) 73 100 130
Osmolarity (mosmol/l) 750
Osmolality (mosmol/kg.water) 870
Further additions can be added to the bags for an expiry of 6 days at 2-8°C followed by 24 hours at 20 - 25°C** These values are maximum totals and include contribution from the bag
Sodium (mmol) 150 250 350
Potassium (mmol) 150 250 350
Magnesium (mmol) 10 15 20
Calcium (mmol) 10 15 20
Sodium glycerophosphate (mmol) 30 50 60
Addaven® (ml) 0 - 10 0 - 10 0 - 10
Vitlipid® N Adult (ml) 0 - 10 0 - 10 0 - 10
Solivito® N (vial) 0 - 1 0 - 1 0 - 1

All figures are approximate.

For further information please contact Fresenius Kabi Limited Medical Information on 01928 533575 or via email at medical.information-UK@fresenius-kabi.com                                        
*          Contribution from both the lipid emulsion and the amino acid solution.
**        Must be stored between 2 - 8C. Protect from light. Vitamin C may be partly oxidised during storage. Additions made to SmofKabiven Low Osmo Peripheral are outside the scope of the product licence.
The mixing of licensed products results in the formation of an unlicensed product.

Kabiven®7

(amino acids, electrolytes, glucose, lipid emulsion)

Kabiven® Peripheral8

(amino acids, electrolytes, glucose, lipid emulsion)  

  Kabiven (central) 8gN Kabiven (central) 11gN Kabiven (central) 14gN Kabiven Peripheral 5gN Kabiven Peripheral 7gN Kabiven Peripheral 9gN
Volume (ml) 1540 2053 2566 1440 1920 2400
Amino acids (g) 51 68 85 34 45 57
Nitrogen (g) 8.1 10.8 13.5 5.4 7.2 9
Fat (g) 60 80 100 51 68 85
Glucose (g) 150 200 250 97 130 162
Energy
Total (Kcal) 1400 1900 2300 1000 1400 1700
Non-protein (Kcal) 1200 1600 2000 900 1200 1500
Lipid (Kcal) 600 800 1000 510 680 850
Carbohydrate (Kcal) 600 800 1000 390 520 650
N:Non-protein energy (g:Kcal) 1:148 1:148 1:148 1:167 1:167 1:167
Energy ratio Carbohydrate:Lipid (%:%) 50:50 50:50 50:50 43:57 43:57 43:57
Electrolyte contents in the bags
Sodium (mmol) 48 64 80 32 43 53
Potassium (mmol) 36 48 60 24 32 40
Magnesium (mmol) 6 8 10 4 5.3 6.7
Calcium (mmol) 3 4 5 2 2.7 3.3
Phosphate (mmol)* 15 20 25 11 14 18
Chloride (mmol) 70 93 116 47 62 78
Acetate (mmol) 58 78 97 39 52 65
Osmolarity (mosmol/l) 1060 750
Osmolality (mosmol/kg.water) 1230 830
Further additions can be added to the bags for an expiry of 6 days at 2-8°C followed by 24 hours at 20-25°C** These values are maximum totals and include contribution from the bag
Sodium (mmol) 231 308 385 216 288 360
Potassium (mmol) 231 308 385 216 288 360
Magnesium (mmol) 8 10 13 7.2 10 12
Calcium (mmol) 8 10 13 7.2 10 12
Inorganic phosphate (mmol) OR Sodium glycerophosphate (mmol) 23
OR
46		 31
OR
62		 38
OR
77		 22
OR
43		 29
OR
58		 36
OR
72
Dipeptiven® (ml)† 200 300 300 200 300 300
Addaven® (ml)† 12.4 16.5 20 12 16 20
Solivito® (Vial)† 2 2 2 2 2 2
Vitlipid® N Adult (ml)† 20 20 20 20 20 20
Extra maximum volumes that can be added to the bag**
Glucose 5% (ml) 0-1000 0-1000 0-1000 0-1000 0-1000 0-1000
NaCl 0.9% (ml) 0-1000 0-1000 0-1000 0-1000 0-1000 0-1000
Water for injection (ml) 0-1000 0-1000 0-1000 0-1000 0-1000 0-1000

All figures are approximate.

* Contribution from both the lipid and the amino acid solution.
** Must be stored between 2-8˚C. Extended stability may be available. Please contact Fresenius Kabi Medical Information if required. Additions made to Kabiven are outside the scope of the product licence. The mixing of licensed products results in the formation of an unlicensed product.
† For further information on these additions please contact Fresenius Kabi Limited Medical Information on 01928 533575 or via email at medical.information-UK@fresenius-kabi.com

 

GB-3CB-2300017 | October 2023
Adverse events should be reported. Reporting forms and information can be found at https://yellowcard.mhra.gov.uk. Adverse events should also be reported to Fresenius Kabi Limited.
Email: Pharmacovigilance.GB@fresenius-kabi.com
References

 Prescribing Informationtds